Epigenetic state determines the in vivo efficacy of STING agonist therapy
R Falahat, A Berglund, P Perez-Villarroel… - Nature …, 2023 - nature.com
While STING-activating agents have shown limited efficacy in early-phase clinical trials,
multiple lines of evidence suggest the importance of tumor cell-intrinsic STING function in …
multiple lines of evidence suggest the importance of tumor cell-intrinsic STING function in …
[PDF][PDF] Epigenetic dosage identifies two major and functionally distinct β cell subtypes
The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …
The role of circulating cell-free DNA as an inflammatory mediator after stroke
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Clinical and experimental studies highlighted the complex role of the immune system in the …
Clinical and experimental studies highlighted the complex role of the immune system in the …
Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress
Sustained life stress and low socioeconomic status are among the major causes of aging-
related diseases and decreased life expectancy. Experimental rodent models can help to …
related diseases and decreased life expectancy. Experimental rodent models can help to …
[PDF][PDF] Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …
Low-input and single-cell methods for Infinium DNA methylation BeadChips
Abstract The Infinium BeadChip is the most widely used DNA methylome assay technology
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
Tracking single-cell evolution using clock-like chromatin accessibility loci
Y Xiao, W Jin, L Ju, J Fu, G Wang, M Yu, F Chen… - Nature …, 2024 - nature.com
Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …
Comparative epigenome analysis using Infinium DNA methylation BeadChips
The arrival of the Infinium DNA methylation BeadChips for mice and other nonhuman
mammalian species has outpaced the development of the informatics that supports their use …
mammalian species has outpaced the development of the informatics that supports their use …
Embryo cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas
In vitro fertilization (IVF) is associated with DNA methylation abnormalities and a higher
incidence of adverse pregnancy outcomes. However, which exposure (s), among the many …
incidence of adverse pregnancy outcomes. However, which exposure (s), among the many …
[HTML][HTML] Placental abnormalities are associated with specific windows of embryo culture in a mouse model
LA Vrooman, EA Rhon-Calderon, KV Suri… - Frontiers in Cell and …, 2022 - frontiersin.org
Assisted Reproductive Technologies (ART) employ gamete/embryo handling and culture in
vitro to produce offspring. ART pregnancies have an increased risk of low birth weight …
vitro to produce offspring. ART pregnancies have an increased risk of low birth weight …