Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of
interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Sepsis is a life-threatening organ dysfunction responsible for nearly 270,000 deaths
annually in the United States alone. Nicotinamide adenine dinucleotide (NAD+), an …

Context Severe sepsis is typically characterized by initial cytokine-mediated
hyperinflammation. Whether this hyperinflammatory phase is followed by …

Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high
mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial …

Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were
evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the …

Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host
response to infection”. Contrary to the older definitions, the current one not only focuses on …

Severe systemic inflammatory response to infection results in severe sepsis and septic
shock, which are the leading causes of death in critically ill patients. Septic shock is …

Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …