Non-small cell lung cancer targeted therapy: drugs and mechanisms of drug resistance

J Wu, Z Lin - International journal of molecular sciences, 2022 - mdpi.com
The advent of precision medicine has brought light to the treatment of non-small cell lung
cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting …

Emerging therapeutics and evolving assessment criteria for intracranial metastases in patients with oncogene-driven non-small-cell lung cancer

K Pan, K Concannon, J Li, J Zhang… - Nature Reviews …, 2023 - nature.com
The improved survival outcomes of patients with non-small-cell lung cancer (NSCLC),
largely owing to the improved control of systemic disease provided by immune-checkpoint …

Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in non-small cell lung cancer

S Popat, SV Liu, N Scheuer, GG Hsu, A Lockhart… - Nature …, 2022 - nature.com
As advanced non-small cell lung cancer (aNSCLC) is being increasingly divided into rare
oncogene-driven subsets, conducting randomised trials becomes challenging. Using real …

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

K Pang, W Wang, JX Qin, ZD Shi, L Hao, YY Ma… - MedComm, 2022 - Wiley Online Library
Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

Current treatments for non-small cell lung cancer

Q Guo, L Liu, Z Chen, Y Fan, Y Zhou, Z Yuan… - Frontiers in …, 2022 - frontiersin.org
Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …

Non–Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology

GJ Riely, DE Wood, DS Ettinger, DL Aisner… - Journal of the National …, 2024 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non–Small Cell
Lung Cancer (NSCLC) provide recommendations for the treatment of patients with NSCLC …

Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

C Bourreau, L Treps, S Faure, D Fradin… - Pharmacology & …, 2023 - Elsevier
While new targeted therapies have considerably changed the treatment and prognosis of
non-small cell lung cancer (NSCLC), they are frequently unsuccessful due to primary or …

[PDF][PDF] Advances in Targeted Therapy Against Driver Mutations and Epigenetic Alterations in Non-Small Cell Lung Cancer.

J Shi, Y Chen, C Peng, L Kuang, Z Zhang… - … (Tech Science Press), 2022 - researchgate.net
The incidence and mortality of lung cancer rank top three of all cancers worldwide.
Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) …

A nonneglectable stereochemical factor in drug development: Atropisomerism

YD Yang, BB Yang, L Li - Chirality, 2022 - Wiley Online Library
Chirality is one of the key factors affecting the medicinal efficacy of compounds. In addition to
central chirality, sterically hindered chiral axes commonly appear in drugs and the resulting …