Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …

The FDA modernisation Act 2.0 marks a game-changing legislation enabling drug
registration without the absolute requirement for the use of animals in safety toxicology …

Augmenting adaptive immunity is a critical goal for developing next-generation cancer
therapies. T and B cells infiltrating the tumor dramatically influence cancer progression …

Towards in vitro models for reducing or replacing the use of animals in drug testing | Nature
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …

Bioprinting in space is the next frontier in tissue engineering. In the absence of gravity, novel
opportunities arise, as well as new challenges. The cardiovascular system needs particular …

Cell-cell interactions underlay organ formation and function during homeostasis. Changes in
communication between cells and their surrounding microenvironment are a feature of …

The liver is the primary organ responsible for the detoxification and metabolism of drugs. To
date, a lack of preclinical models that accurately emulate drug metabolism by the human …