Introduction The use of activated charcoal in poisoning remains both a pillar of modern
toxicology and a source of debate. Following the publication of the joint position statements …

CPT-11 (irinotecan), a DNA topoisomerase I inhibitor is one of the main treatments for
colorectal cancer. The main dose limiting toxicities are neutropenia and late onset diarrhea …

Background: Irinotecan is widely used in the treatment of various solid tumors, but the
adverse effects from it, especially diarrhea, limit its use. Several clinical trials of prophylactic …

Background We performed a prospective study to evaluate the efficacy of activated charcoal
(AC) to prevent irinotecan‐induced diarrhea (IID). Procedure We designed a prospective …

Abstract Irinotecan (CPT-11) treatments induce severe diarrhoea at a rate of> 40%. In
clinical trials, we evaluated the preventing effects of oral alkalization, which has been …

Purpose One of the significant dose-limiting toxicities of irinotecan hydrochloride (CPT-11) is
severe diarrhea due to impairment of the intestinal membrane induced by the excreted CPT …

Allometry has been extensively used in the modern day drug development scenario to
predict the human relevant parameters (clearance, CI, and volume of distribution at steady …