Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose

LCG Hoegberg, G Shepherd, DM Wood… - Clinical …, 2021 - Taylor & Francis
Introduction The use of activated charcoal in poisoning remains both a pillar of modern
toxicology and a source of debate. Following the publication of the joint position statements …

Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis

U Swami, S Goel, S Mani - Current drug targets, 2013 - ingentaconnect.com
CPT-11 (irinotecan), a DNA topoisomerase I inhibitor is one of the main treatments for
colorectal cancer. The main dose limiting toxicities are neutropenia and late onset diarrhea …

Efficiency of Protective Interventions on Irinotecan-Induced Diarrhea: A Systematic Review and Meta-Analysis

Y He, L Wu, X Qi, X Wang, B He… - Integrative Cancer …, 2024 - journals.sagepub.com
Background: Irinotecan is widely used in the treatment of various solid tumors, but the
adverse effects from it, especially diarrhea, limit its use. Several clinical trials of prophylactic …

Activated charcoal to prevent irinotecan‐induced diarrhea in children

GC Sergio, GM Félix, JV Luis - Pediatric blood & cancer, 2008 - Wiley Online Library
Background We performed a prospective study to evaluate the efficacy of activated charcoal
(AC) to prevent irinotecan‐induced diarrhea (IID). Procedure We designed a prospective …

Prevention of irinotecan-induced diarrhoea by oral carbonaceous adsorbent (Kremezin™) in cancer patients

Y Maeda, T Ohune, M Nakamura… - Oncology …, 2004 - spandidos-publications.com
Abstract Irinotecan (CPT-11) treatments induce severe diarrhoea at a rate of> 40%. In
clinical trials, we evaluated the preventing effects of oral alkalization, which has been …

Adsorption of irinotecan onto oral adsorbent AST-120 (KremezinTM) for preventing delayed diarrhea

M Hidaka, K Yamasaki, M Okumura, T Ogikubo… - Cancer chemotherapy …, 2007 - Springer
Purpose One of the significant dose-limiting toxicities of irinotecan hydrochloride (CPT-11) is
severe diarrhea due to impairment of the intestinal membrane induced by the excreted CPT …

Allometric Scaling of a Metabolically Complex Camptothecin Analog

P Ahlawat, NR Srinivas - Arzneimittelforschung, 2009 - thieme-connect.com
Allometry has been extensively used in the modern day drug development scenario to
predict the human relevant parameters (clearance, CI, and volume of distribution at steady …