Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Rab GTPases comprise a large family of conserved GTPases that are critical regulators of
the secretory and endocytic pathways. The human genome encodes~ 65 Rabs that localize …

Cells sense physical forces and convert them into electrical or chemical signals, a process
known as mechanotransduction. Whereas extensive studies focus on mechanotransduction …

Cells keep their proteome functional by the action of the proteostasis network, composed of
the chaperones, the ubiquitin-proteasome system and autophagy. The decline of this …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor
neurons. Recently, genome-wide association studies identified KIF5A as a new ALS …

Axonal transport is essential for neuronal survival. This is driven by microtubule motors
including dynein, which transports cargo from the axon tip back to the cell body. This …

Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), increasing
phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2 …

Deficits in mitochondrial transport are a common feature of neurodegenerative diseases. We
investigated whether loss of components of the mitochondrial transport machinery impinge …

Bidirectional cargo transport in neurons requires competing activity of motors from the
kinesin-1,-2, and-3 superfamilies against cytoplasmic dynein-1. Previous studies …

Cells are equipped with asymmetrically localised and functionally specialised components,
including cytoskeletal structures and organelles. Positioning these components to specific …