This article aims to promote integration of angiogenesis-related models, both integration of
the work described herein and many other existing and future models. Integration of …

Cellular signaling operates in a noisy environment shaped by low molecular concentrations
and cellular heterogeneity. For calcium release through intracellular channels–one of the …

The Virtual Cell (VCell; http://vcell. org/) is a problem solving environment, built on a central
database, for analysis, modelling and simulation of cell biological processes. VCell …

Regulation of enzyme activity and biocatalytic cascades on compartmentalized cellular
components is key to the adaptation of cellular processes such as signal transduction and …

Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal
modulators include multiple messengers and signaling pathways with complex …

Signal-induced Ca 2+ oscillations have been observed in many cell types and play a
primary role in cell physiology. Although it is the regular character of these oscillations that …

Biological processes involve a variety of spatial and temporal scales. A holistic
understanding of many biological processes therefore requires multi-scale models which …

Abstract Design patterns are generalized solutions to frequently recurring problems. They
were initially developed by architects and computer scientists to create a higher level of …

One of the major factors distinguishing molecular processes in vivo from biochemical
experiments in vitro is the effect of the environment produced by macromolecular crowding …

Solid tumors require the formation of new blood vessels to support their growth,
invasiveness and metastatic potential. Tumor neovascularization is achieved by …