Brain neural patterns and the memory function of sleep

G Girardeau, V Lopes-dos-Santos - Science, 2021 - science.org
Sleep is crucial for healthy cognition, including memory. The two main phases of sleep, REM
(rapid eye movement) and non-REM sleep, are associated with characteristic …

Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans

M Geva-Sagiv, EA Mankin, D Eliashiv, S Epstein… - Nature …, 2023 - nature.com
Memory consolidation during sleep is thought to depend on the coordinated interplay
between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but …

Hippocampal CA2 sharp-wave ripples reactivate and promote social memory

A Oliva, A Fernández-Ruiz, F Leroy, SA Siegelbaum - Nature, 2020 - nature.com
The consolidation of spatial memory depends on the reactivation ('replay') of hippocampal
place cells that were active during recent behaviour. Such reactivation is observed during …

The role of inhibitory circuits in hippocampal memory processing

L Topolnik, S Tamboli - Nature Reviews Neuroscience, 2022 - nature.com
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

HR Joo, LM Frank - Nature Reviews Neuroscience, 2018 - nature.com
Various cognitive functions have long been known to require the hippocampus. Recently,
progress has been made in identifying the hippocampal neural activity patterns that …

Selective experience replay for lifelong learning

D Isele, A Cosgun - Proceedings of the AAAI Conference on Artificial …, 2018 - ojs.aaai.org
Deep reinforcement learning has emerged as a powerful tool for a variety of learning tasks,
however deep nets typically exhibit forgetting when learning multiple tasks in sequence. To …

The role of engram cells in the systems consolidation of memory

S Tonegawa, MD Morrissey, T Kitamura - Nature Reviews …, 2018 - nature.com
What happens to memories as days, weeks and years go by has long been a fundamental
question in neuroscience and psychology. For decades, researchers have attempted to …

Navigating for reward

M Sosa, LM Giocomo - Nature Reviews Neuroscience, 2021 - nature.com
An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

AK Gillespie, DAA Maya, EL Denovellis, DF Liu… - Neuron, 2021 - cell.com
Executing memory-guided behavior requires storage of information about experience and
later recall of that information to inform choices. Awake hippocampal replay, when …