Computational analysis of cancer genome sequencing data
Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …
comprehensive identification of somatic alterations using rigorous computational methods …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
A clinically applicable integrative molecular classification of meningiomas
Meningiomas are the most common primary intracranial tumour in adults. Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …
symptoms are generally treated with surgery as there are no effective medical therapies. The …
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Y Hoogstrate, K Draaisma, SA Ghisai, L van Hijfte… - Cancer Cell, 2023 - cell.com
A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq)(n= 322 test …
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia
F Nadeu, R Royo, R Massoni-Badosa… - Nature medicine, 2022 - nature.com
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial
N van Dijk, A Gil-Jimenez, K Silina, K Hendricksen… - Nature medicine, 2020 - nature.com
Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown
remarkable pathological responses in melanoma and colorectal cancer. In NABUCCO …
remarkable pathological responses in melanoma and colorectal cancer. In NABUCCO …
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Abstract Tumor protein p53 (TP53) is the most frequently mutated gene in cancer,. In
patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high …
patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high …
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
M Kim, H Mun, CO Sung, EJ Cho, HJ Jeon… - Nature …, 2019 - nature.com
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals,
driving a need for personalised medicine. Here, we report lung cancer organoids and …
driving a need for personalised medicine. Here, we report lung cancer organoids and …