[HTML][HTML] Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

[HTML][HTML] Targeting tumor-associated macrophages to synergize tumor immunotherapy

X Xiang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

G Eraslan, E Drokhlyansky, S Anand, E Fiskin… - Science, 2022 - science.org
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Macrophage-based approaches for cancer immunotherapy

NR Anderson, NG Minutolo, S Gill, M Klichinsky - Cancer research, 2021 - AACR
Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …

Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment

X Zhao, D Pei, Y Yang, K Xu, J Yu… - Advanced functional …, 2021 - Wiley Online Library
Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal
wound dressings that can integrate matching mechanical strength, fast self‐healability, facile …

The tumor microenvironment innately modulates cancer progression

DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

[PDF][PDF] BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment

B Cirovic, LCJ de Bree, L Groh, BA Blok, J Chan… - Cell host & …, 2020 - cell.com
Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates
beneficial heterologous effects, but the mechanisms underlying its persistence and …

[HTML][HTML] Hematological methods in fish–Not only for beginners

M Witeska, E Kondera, K Ługowska, B Bojarski - Aquaculture, 2022 - Elsevier
Hematological analyses are commonly used to evaluate fish health and welfare in
aquaculture, veterinary practice and scientific research. Hematological parameters were …

[HTML][HTML] More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis

M Gschwandtner, R Derler, KS Midwood - Frontiers in immunology, 2019 - frontiersin.org
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

[HTML][HTML] Tumor-associated macrophages: recent insights and therapies

J Zhou, Z Tang, S Gao, C Li, Y Feng, X Zhou - Frontiers in oncology, 2020 - frontiersin.org
Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …