Cells interact with their surrounding environment through a combination of static and
dynamic mechanical signals that vary over stimulus types, intensity, space, and time …

Near-infrared (NIR) light possesses many suitable optophysical properties for medical
imaging including low autofluorescence, deep tissue penetration, and minimal light …

Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are
used clinically, eg, to induce immunity against cancer. However, their physiological …

Macrophages (Mfs) are instrumental in maintaining immune homeostasis in the intestine, yet
studies on the origin and heterogeneity of human intestinal Mfs are scarce. Here, we …

Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Macrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases.
In fact, during these diseases, activated macrophages may play a critical role, promoting the …

The important role of macrophages in host defense against a variety of pathogens has long
been recognized and has been documented and reviewed in numerous publications …

Macrophages contribute to the activation of fibroblastic cells into myofibroblasts, which
secrete collagen and contract the collagen matrix to acutely repair injured tissue. Persistent …

Technological advances enable assaying multiplexed spatially resolved RNA and protein
expression profiling of individual cells, thereby capturing molecular variations in …