Magnesium is well known for its diverse actions within the human body. From a neurological
standpoint, magnesium plays an essential role in nerve transmission and neuromuscular …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Manganese (Mn) is an essential trace element necessary for physiological processes that
support development, growth and neuronal function. Secondary to elevated exposure or …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Hydroethidine (HE) or dihydroethidium (DHE), a redox-sensitive probe, has been widely
used to detect intracellular superoxide anion. It is a common assumption that the reaction …

It is now clear that apoptosis does not constitute the sole genetically encoded form of cell
death. Rather, cells can spontaneously undertake or exogenously be driven into a cell death …

In the past few years it has become apparent that mitochondria have an essential role in the
life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic …

Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …