Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

Abstract S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during
many acute and chronic inflammatory disorders. However, the precise mechanism of its …

NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of
proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this …

Pyroptosis is a form of cell death triggered by the innate immune system that has been
implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level …

Significance: Inflammasomes are cytosolic multiprotein complexes that mediate innate
immune pathways. Inflammasomes activate inflammatory caspases and regulate …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Inflammation, when properly mounted and precisely calibrated, is a beneficial process that
enables the rapid removal of invading pathogens and/or cellular corpses and promotes …