Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Abstract Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal
transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to …

Osteoarthritis (OA) is a common degenerative disease of articular cartilage, and there is
currently no effective treatment. Baicalein, a flavonoid extracted from plants of the Scutellaria …

Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA)
development and progression. Methods Destabilisation of the medial meniscus (DMM) …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Doxorubicin (Dox) is widely used in chemotherapy regimens for several malignant
conditions. Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of
nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism …

Chemotherapy is one of the standard methods for the treatment of malignant tumors. It aims
to cause lethal damage to cellular structures, mainly DNA. Noteworthy, in recent years …