Botulinum neurotoxin A (BoNT/A) is a toxin produced by the naturally-occurring Clostridium
botulinum that causes botulism. The potential of BoNT/A as a useful medical intervention …

Chronic neuropathic pain is often a severe and inadequately treated consequence of spinal
cord injury (SCI). Recent findings suggest that SCI pain is promoted by spontaneous activity …

The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although
traditionally associated with analgesic activity, recent studies have shown that capsaicin has …

Type 2 diabetes (T2D) is a high-risk factor for Alzheimer's disease (AD) due to impaired
insulin signaling pathway in brain. Capsaicin is a specific transient receptor potential …

Introduction Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory
system, which can severely impact patients' quality of life. The current-approved treatments …

This review aims to create an overview of the currently available results of site-directed
mutagenesis studies on transient receptor potential vanilloid type 1 (TRPV1) receptor …

Cancer progression is a complex multistep process comprising of angiogenesis of the
primary tumor, its invasion into the surrounding stroma and its migration to distant organs to …

Capsaicin is a potent agonist of the TRPV1 channel, a transduction channel that is highly
expressed in nociceptive fibers (pain fibers) throughout the peripheral nervous system …

Capsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its
hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including …

The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses …