Chronic cough and pain: Janus faces in sensory neurobiology?

J O'Neill, SB McMahon, BJ Undem - Pulmonary pharmacology & …, 2013 - Elsevier
Both chronic cough and chronic pain are critical clinical issues in which a large number of
patients remain unsatisfied with available treatments. These conditions have considerable …

The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor

S Xiao, Y Zhang, P Song, J Xie, G Pang - Biosensors and Bioelectronics, 2019 - Elsevier
In this study, a taste bud tissue biosensor was prepared by a starch-sodium alginate cross-
linking fixation method. Capsaicin was used as a TRPV1 noxious ion channel activator to …

Oropharyngeal and laryngeal sensory innervation in the pathophysiology of swallowing disorders and sensory stimulation treatments

D Alvarez‐Berdugo, L Rofes… - Annals of the New …, 2016 - Wiley Online Library
Oropharyngeal dysphagia (OD) affects older and neurological patients, causing malnutrition
and dehydration and increasing the risk for aspiration pneumonia. There is evidence that …

Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile in vitro

M Azimirad, M Noori, F Azimirad, F Gholami… - Annals of Clinical …, 2022 - Springer
Background The dramatic upsurge of Clostridioides difficile infection (CDI) by hypervirulent
isolates along with the paucity of effective conventional treatment call for the development of …

Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients

C Lozano, C Córdova, I Marchant… - … Cancer: Targets and …, 2018 - Taylor & Francis
Background Breast cancer is a malignant disease that represents an important public health
burden. The description of new molecular markers can be important to diagnosis …

An overview of offset analgesia and the comparison with conditioned pain modulation: a systematic literature review

L Hermans, P Calders, J Van Oosterwijck… - Pain …, 2016 - repository.uantwerpen.be
Background: Offset analgesia (OA) is an increasingly described phenomenon to measure
endogenous pain inhibition, in which a greater decrease in pain intensity is experienced …

[HTML][HTML] Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats

JT Da Silva, Y Zhang, J Asgar, JY Ro… - Behavioural brain …, 2018 - Elsevier
Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has
been investigated as a potential mechanism for the differences in pain modulation observed …

辣椒素药理活性及其药物代谢动力学的研究进展

蒋能, 汤春丽, 吴慧娴, 颜志明 - 天然产物研究与开发, 2022 - trcw.ac.cn
辣椒素家族是辣椒中含量很高的活性成分, 具有抗氧化, 抗肿瘤, 抗胃肠道溃疡,
减肥及镇痛等方面的药理作用. 研究表明, 辣椒素的药理活性取决于剂量, 给药途径和不同组织中 …

Natural products and some semi-synthetic analogues as potential TRPV1 ligands for attenuating neuropathic pain

GG Naik, A Uniyal, D Chouhan… - Current …, 2022 - ingentaconnect.com
Natural products and leads inspired by them have acted as a probe for successful drug
discovery for many decades. Pain is an obnoxious sensory and emotional experience …

Transient receptor potential channels and energy homeostasis

GP Ahern - Trends in Endocrinology & Metabolism, 2013 - cell.com
Transient receptor potential (TRP) channels are members of an ancient class of ion
channels that are present in most mammalian tissues. Consistent with their wide tissue …