Plasmodium vivax is an important cause of malaria, associated with a significant public
health burden. Whilst enhanced malaria-control activities have successfully reduced the …

Highlights•Chloroquine is used for anti-malaria, anti-cancer and anti-virus treatment.•The
efficacy of hydroxychloroquine against COVID-19 is controversial.•Several quinoline …

Malaria is a global parasitic infection that leads to substantial illness and death. The most
commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but …

Plasmodium vivax and Plasmodium ovale form dormant liver hypnozoites that can reactivate
weeks to months following initial infection. Malaria recurrences caused by relapses are an …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Initiatives to eradicate malaria have a good impact on P. falciparum malaria worldwide. P.
vivax, however, still presents significant difficulties. This is due to its unique biological traits …

Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …

Background Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects~ 6–7
million people worldwide. Significant limitations still exist in our understanding of CD …

Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows
existing and approved clinical drugs to be innovatively repurposed to treat tumors. Based on …