Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

Alcohol use disorder is associated with several mental, physical, and social problems. Its
treatment is difficult and often requires a combination of pharmacological and behavioural …

Rationale Alcohol use disorder remains a leading cause of preventable deaths, and current
treatments have limited efficacy. Glucagon-like peptide 1 (GLP-1) receptor agonists can …

Alcohol use disorder (AUD) is a severe, yet not fully understood, mental health problem. It is
associated with liver, pancreatic, and gastrointestinal diseases, thereby highly increasing …

Histamine H 3 receptors are widely distributed G i-coupled receptors whose activation
reduces neuronal activity and inhibits release of numerous neurotransmitters. Although …

Central histaminergic H3 receptor (H3R) has been extensively investigated as a potential
therapeutic target for various neurological and neurodegenerative disorders. Despite …

Histamine and its receptors in the nervous system received recognition late in comparison to
the other aminergic transmitters, after the detection of histaminergic neurons in the posterior …

Background Alcohol is a major abused drug worldwide that contributes substantially to
health and social problems. These problems result from acute alcohol overuse as well as …

Substance use disorders are a leading cause of morbidity and mortality, and available
pharmacological treatments are of modest efficacy. Histamine is a biogenic amine with four …

Abstract Histamine H 3 receptors (H 3 R) have attracted interest of research groups as drug
target to several CNS disorders. Data suggests that H 3 R antagonists exert neuroprotective …