DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …

This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and
nitrating species, and it may play an important role in the pathophysiology of inflammation …

Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as
being detrimental to cellular components such as DNA. The genome and transcriptome …

Reactive oxygen species (ROS) are now appreciated to play several important roles in a
number of biological processes and regulate cell physiology and function. ROS are a …

Wastewater effluent is a major source of extracellular antibiotic resistance genes (eArGs) in
the aquatic environment, a threat to human health and biosecurity. However, little is known …

Although the terms “excessive reactive oxygen species (ROS)” and “oxidative stress” are
widely used, the implications of oxidative stress are often misunderstood. ROS are not a …

Abstract The Genetic Toxicology Technical Committee (GTTC) of the Health and
Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) …

Excited triplet states of wastewater effluent organic matter (3EfOM*) are known as important
photo-oxidants in the degradation of extracellular antibiotic resistance genes (eArGs) in …

Abstract The Base Excision Repair (BER) pathway is a highly conserved DNA repair system
targeting subtle chemical base modifications that arise from oxidation, deamination and …