DNA damage by reactive species: Mechanisms, mutation and repair

NR Jena - Journal of biosciences, 2012 - Springer
DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

The current state of eukaryotic DNA base damage and repair

NC Bauer, AH Corbett, PW Doetsch - Nucleic acids research, 2015 - academic.oup.com
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …

[HTML][HTML] Chemical insights into oxidative and nitrative modifications of DNA

CMC Andrés, JMP Lastra, CA Juan, FJ Plou… - International Journal of …, 2023 - mdpi.com
This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and
nitrating species, and it may play an important role in the pathophysiology of inflammation …

Formation and processing of DNA damage substrates for the hNEIL enzymes

AM Fleming, CJ Burrows - Free Radical Biology and Medicine, 2017 - Elsevier
Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as
being detrimental to cellular components such as DNA. The genome and transcriptome …

Reactive oxygen species: physiological roles in the regulation of vascular cells

D Vara, G Pula - Current molecular medicine, 2014 - ingentaconnect.com
Reactive oxygen species (ROS) are now appreciated to play several important roles in a
number of biological processes and regulate cell physiology and function. ROS are a …

Triplet photochemistry of effluent organic matter in degradation of extracellular antibiotic resistance genes

J Peng, Y Pan, Y Zhou, Q Kong, Y Lei… - Environmental …, 2023 - ACS Publications
Wastewater effluent is a major source of extracellular antibiotic resistance genes (eArGs) in
the aquatic environment, a threat to human health and biosecurity. However, little is known …

Excessive reactive oxygen species and exotic DNA lesions as an exploitable liability

SF AbdulSalam, FS Thowfeik, EJ Merino - Biochemistry, 2016 - ACS Publications
Although the terms “excessive reactive oxygen species (ROS)” and “oxidative stress” are
widely used, the implications of oxidative stress are often misunderstood. ROS are not a …

AOP report: development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

E Cho, A Allemang, M Audebert… - Environmental and …, 2022 - Wiley Online Library
Abstract The Genetic Toxicology Technical Committee (GTTC) of the Health and
Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) …

Mechanistic Aspects of Photodegradation of Deoxynucleosides Induced by Triplet State of Effluent Organic Matter

J Peng, Y Pan, Y Zhou, X Lei, Y Guo, Y Lei… - Environmental …, 2024 - ACS Publications
Excited triplet states of wastewater effluent organic matter (3EfOM*) are known as important
photo-oxidants in the degradation of extracellular antibiotic resistance genes (eArGs) in …

[HTML][HTML] Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair …

CH Trasviña-Arenas, M Demir, WJ Lin, SS David - DNA repair, 2021 - Elsevier
Abstract The Base Excision Repair (BER) pathway is a highly conserved DNA repair system
targeting subtle chemical base modifications that arise from oxidation, deamination and …