Tuberculosis, caused by Mycobacterium tuberculosis (Mtb) is an ancient disease that has
remained a leading cause of infectious death. Mtb has evolved drug resistance to every …

Standardised management of tuberculosis may soon be replaced by individualised,
precision medicine-guided therapies informed with knowledge provided by the field of …

Background The rise of antimicrobial drug resistance in Mycobacterium tuberculosis
coupled with the shortage of new antibiotics has elevated TB to a major global health …

Multi-omics strategies are indispensable tools in the search for new anti-tuberculosis drugs.
Omics methodologies, where the ensemble of a class of biological molecules are measured …

CRISPR screening, including CRISPR interference (CRISPRi) and CRISPR-knockout
(CRISPR-KO) screening, has become a powerful technology in the genetic screening of …

Mycobacteria are members of the Actinomycetales order, and they are classified into one
family, Mycobacteriaceae. More than 20 mycobacterial species cause disease in humans …

Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new
treatments for TB is hindered by the large number of candidate drugs, drug combinations …

Drug combinations are a promising strategy to counter antibiotic resistance. However,
current experimental and computational approaches do not account for the entire complexity …

Whole cell-based phenotypic screens have become the primary mode of hit generation in
tuberculosis (TB) drug discovery during the last two decades. Different drug screening …

Transposon-based strategies provide a powerful and unbiased way to study the bacterial
stress response,,,,,,–, but these approaches cannot fully capture the complexities of network …