With the rapid global spread of SARS-CoV-2, we have become acutely aware of the
inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life …

Transcriptional responses in bacteria following antibiotic exposure offer insights into
antibiotic mechanism of action, bacterial responses, and characterization of antimicrobial …

Whole cell-based phenotypic screens have become the primary mode of hit generation in
tuberculosis (TB) drug discovery during the last two decades. Different drug screening …

Transposon-based strategies provide a powerful and unbiased way to study the bacterial
stress response,,,,,,–, but these approaches cannot fully capture the complexities of network …

Combination therapy is necessary to treat tuberculosis to decrease the rate of disease
relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently …

To address the ongoing global tuberculosis crisis, there is a need for shorter, more effective
treatments. A major reason why tuberculosis requires prolonged treatment is that, following …

Shorter and more effective treatment regimens as well as new drugs are urgent priorities for
reducing the immense global burden of tuberculosis (TB). As treatment of TB currently …

Summary Tuberculosis (TB) afflicted 10.6 million people in 2021, and its global burden is
increasing due to multidrug-resistant TB (MDR-TB) and extensively resistant TB (XDR-TB) …

Combination therapy has, to some extent, been successful in limiting the emergence of drug-
resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting …

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium
tuberculosis. According to the WHO, the disease is one of the top 10 causes of death of …