Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases

J Reiser, XY Zhang, CS Hemenway… - Expert opinion on …, 2005 - Taylor & Francis
The intriguing biology of stem cells and their vast clinical potential is emerging rapidly for
gene therapy. Bone marrow stem cells, including the pluripotent haematopoietic stem cells …

Tumour cell–derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth

H Haga, IK Yan, K Takahashi, J Wood… - Journal of …, 2015 - Taylor & Francis
The contributions of mesenchymal stem cells (MSCs) to tumour growth and stroma formation
are poorly understood. Tumour cells can transfer genetic information and modulate cell …

Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy

M Wankhede, A Bouras, M Kaluzova… - Expert review of …, 2012 - Taylor & Francis
Magnetic nanoparticles (MNPs) represent a promising nanomaterial for the targeted therapy
and imaging of malignant brain tumors. Conjugation of peptides or antibodies to the surface …

A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs

X Chen, X Lin, J Zhao, W Shi, H Zhang, Y Wang… - Molecular Therapy, 2008 - cell.com
The poor prognosis for patients with advanced malignancy relates partly to the inability to
reverse cancer metastasis. In this study we have investigated an integrated immunotherapy …

Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts

P Secchiero, S Zorzet, C Tripodo, F Corallini, E Melloni… - PloS one, 2010 - journals.plos.org
Background Although multimodality treatment can induce high rate of remission in many
subtypes of non-Hodgkin's lymphoma (NHL), significant proportions of patients relapse with …

Gene therapy of intracranial glioma using interleukin 12–secreting human umbilical cord blood–derived mesenchymal stem cells

CH Ryu, SH Park, SA Park, SM Kim, JY Lim… - Human gene …, 2011 - liebertpub.com
Clinical trials of gene therapy using a viral delivery system for glioma have been limited.
Recently, gene therapy using stem cells as the vehicles for delivery of therapeutic agents …

Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice

L Kucerova, M Matuskova… - The Journal of Gene …, 2008 - Wiley Online Library
Background Previously, we validated capability of human adipose tissue‐derived
mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles for gene‐directed enzyme …

Dielectrophoresis: An assessment of its potential to aid the research and practice of drug discovery and delivery

R Pethig - Advanced drug delivery reviews, 2013 - Elsevier
Dielectrophoresis (DEP) is an electrokinetic technique with proven ability to discriminate and
selectively manipulate cells based on their phenotype and physiological state, without the …

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles

B Hall, J Dembinski, AK Sasser, M Studeny… - International journal of …, 2007 - Springer
Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors,
where they contribute to the formation of tumor-associated stroma. This effect can be …

Role of stem cells in cancer therapy and cancer stem cells: a review

J Sagar, B Chaib, K Sales, M Winslet… - Cancer cell international, 2007 - Springer
For over 30 years, stem cells have been used in the replenishment of blood and immune
systems damaged by the cancer cells or during treatment of cancer by chemotherapy or …