In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Background Cancers with a defective DNA mismatch repair (dMMR) system contain
thousands of mutations most frequently located in monomorphic microsatellites and are …

Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

The strongest nonmodifiable risk factors for CRC and precancerous polyps are age, male
sex, and family history of CRC. Current evidence indicates that smoking, obesity, and diet …

Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …

Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for …

The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk
Assessment: Breast and Ovarian provide recommendations for genetic testing and …

PURPOSE To provide resource-stratified, evidence-based recommendations on the early
detection of colorectal cancer in four tiers to clinicians, patients, and caregivers. METHODS …

The incidence of early-onset colorectal—ie, colorectal cancer cancer diagnosed in patients
under the age of 50 years—has been increasing around the world. This Series paper …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …