Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis

L Chen, Y Liu, Z Wang, L Zhang, Y Xu, Y Li… - … & Molecular Medicine, 2023 - nature.com
Neutrophil extracellular traps (NETs) play an important role in abdominal aortic aneurysm
(AAA) formation; however, the underlying molecular mechanisms remain unclear …

[HTML][HTML] Editor's Choice--European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery …

A Wanhainen, I Van Herzeele, FB Goncalves… - European Journal of …, 2024 - Elsevier
Abstract Objective The European Society for Vascular Surgery (ESVS) has developed
clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta …

The footprint of kynurenine pathway in cardiovascular diseases

M Ala, SP Eftekhar - International Journal of Tryptophan …, 2022 - journals.sagepub.com
Kynurenine pathway is the main route of tryptophan metabolism and produces several
metabolites with various biologic properties. It has been uncovered that several …

BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis

G Zhao, Y Zhao, H Lu, Z Chang, H Liu… - The Journal of …, 2022 - Am Soc Clin Investig
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique
subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is …

Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: a randomized clinical trial

J Golledge, J Pinchbeck, SM Tomee… - JAMA …, 2020 - jamanetwork.com
Importance Currently there is no drug therapy for abdominal aortic aneurysm (AAA).
Objective To test the efficacy of the angiotensin receptor blocker telmisartan in slowing AAA …

Low progesterone and low estradiol levels associate with abdominal aortic aneurysms in men

C Ohlsson, M Langenskiöld, K Smidfelt… - The Journal of …, 2022 - academic.oup.com
Context Male sex is a major risk factor for abdominal aortic aneurysms (AAA) but few studies
have addressed associations between sex hormone levels and AAA. Objective We aimed to …

Mouse models for abdominal aortic aneurysm

J Golledge, SM Krishna, Y Wang - British Journal of …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

N1-methyladenosine (m1A) regulation associated with the pathogenesis of abdominal aortic aneurysm through YTHDF3 modulating macrophage polarization

Y Wu, D Jiang, H Zhang, F Yin, P Guo… - Frontiers in …, 2022 - frontiersin.org
Objectives: This study aimed to identify key AAA-related m1A RNA methylation regulators
and their association with immune infiltration in AAA. Furthermore, we aimed to explore the …