BACKGROUND & AIMS: Growth of many different tumor types requires a population of self-
renewing cancer stem cells (CSCs). c-Met is a marker of normal mouse pancreatic stem and …

At present, a large number of studies have demonstrated that c-Met generally exerts a
crucial function of promoting tumor cells proliferation and differentiation in digestive system …

During pancreatic development, neogenesis, and regeneration, stem cells might act as a
central player to generate endocrine, acinar, and duct cells. Although these cells are well …

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the
invention of a series of novel triazolopyrazine c-Met inhibitors. The structure–activity …

Pancreatic cancer (PaCa) is characterized by dense stroma that hinders treatment efficacy,
with pancreatic stellate cells (PSCs) being a major contributor to this stromal barrier and …

Ovarian cancer is the leading cause of death from gynecological cancers in North America
and Europe. Despite its clinical significance, the factors that regulate the development and …

Purpose The purpose of this study was to identify suitable molecular targets for tumor-
specific imaging of pancreatic adenocarcinoma. Procedures The expression of eight …

Purpose: Pancreatic cancer is an aggressive disease associated with a poor 5-year overall
survival. Most patients are ineligible for surgery due to late diagnosis and are treated …

Overexpression of hepatocyte growth factor receptor (c-met) has been detected in many
human tumors. To investigate the possible involvement of c-met in human gastric …

Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of
hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor …