Molecular testing and targeted therapy for non-small cell lung cancer: current status and perspectives

EN Imyanitov, AG Iyevleva, EV Levchenko - Critical reviews in oncology …, 2021 - Elsevier
Molecular testing has become a mandatory component of the non-small cell lung cancer
(NSCLC) management. The detection of EGFR, BRAF and MET mutations as well as the …

[HTML][HTML] The evolving landscape of biomarker testing for non-small cell lung cancer in Europe

KM Kerr, F Bibeau, E Thunnissen, J Botling, A Ryška… - Lung Cancer, 2021 - Elsevier
The discovery of oncogenic driver mutations rendering non-small cell lung cancer (NSCLC)
targetable by small-molecule inhibitors, and the development of immunotherapies, have …

Genetic markers in lung cancer diagnosis: a review

K Wadowska, I Bil-Lula, Ł Trembecki… - International journal of …, 2020 - mdpi.com
Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of
cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are …

When should we order a next generation sequencing test in a patient with cancer?

R Colomer, R Mondejar, N Romero-Laorden… - …, 2020 - thelancet.com
Technical advances in genome sequencing and the implementation of next-generation
sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient …

Therapeutic advances in non‐small cell lung cancer: Focus on clinical development of targeted therapy and immunotherapy

Y Cheng, T Zhang, Q Xu - MedComm, 2021 - Wiley Online Library
Lung cancer still contributes to nearly one‐quarter cancer‐related deaths in the past
decades, despite the rapid development of targeted therapy and immunotherapy in non …

Identifying the steps required to effectively implement next-generation sequencing in oncology at a national level in Europe

D Horgan, G Curigliano, O Riess, P Hofman… - Journal of personalized …, 2022 - mdpi.com
Next-generation sequencing (NGS) may enable more focused and highly personalized
cancer treatment, with the National Comprehensive Cancer Network and European Society …

Diagnostic, predictive, and prognostic biomarkers in non-small cell lung cancer (NSCLC) management

M Šutić, A Vukić, J Baranašić, A Försti… - Journal of personalized …, 2021 - mdpi.com
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing
efforts for its early detection by screening populations at risk, the majority of lung cancer …

New update to the guidelines on testing predictive biomarkers in non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the …

D Isla, MD Lozano, L Paz-Ares, C Salas… - Clinical and …, 2023 - Springer
Non-small cell lung cancer (NSCLC) presents the greatest number of identified therapeutic
targets, some of which have therapeutic utility. Currently, detecting EGFR, BRAF, KRAS and …

Expert consensus recommendations on biomarker testing in metastatic and nonmetastatic NSCLC in Asia

T Mitsudomi, D Tan, JCH Yang, MJ Ahn, U Batra… - Journal of Thoracic …, 2023 - Elsevier
Introduction Most published guidelines for genomic biomarker testing in NSCLC reflect the
disease epidemiology and treatments readily available in Europe and North America …

Cost-effectiveness of next-generation sequencing versus single-gene testing for the molecular diagnosis of patients with metastatic non–small-cell lung cancer from …

E Arriola, R Bernabé, RG Campelo… - JCO Precision …, 2023 - ascopubs.org
PURPOSE The aim of this study was to assess the cost-effectiveness of using next-
generation sequencing (NGS) versus single-gene testing (SgT) for the detection of genetic …