The overexpression of estrogen receptor alpha (ERalpha) is frequently observed in the early
stage of breast cancer. We previously reported that the specific promoter of the ERalpha …

Estrogen receptor (ER) functions as a transcription factor to induce gene expression events
sufficient for cell division and breast cancer progression. A significant body of work exists on …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

Estrogens are known to regulate the proliferation of breast cancer cells and to alter their
cytoarchitectural and phenotypic properties, but the gene networks and pathways by which …

1α, 25-Dihydroxyvitamin D3 [1, 25 (OH) 2D3] regulates calcium homeostasis and controls
cellular differentiation and proliferation. The vitamin D receptor (VDR) is a ligand-regulated …

Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy,
we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We …

Although estrogen receptors (ERs) recognize 15-bp palindromic estrogen response
elements (EREs) with maximal affinity in vitro, few near-consensus sequences have been …

Nuclear receptors can activate diverse biological pathways within a target cell in response to
their cognate ligands, but how this compartmentalization is achieved at the level of gene …

Background Estrogens and their receptors are important in human development, physiology
and disease. In this study, we utilized an integrated genome-wide molecular and …

Background Estrogen plays a central role in breast cancer pathogenesis and many potent
risk factors for the development of the disease can be explained in terms of increased …