Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …

Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …

Introduction: The concept of privileged structures is well known and is often used in the
process of drug design and development. Although its assumptions are not clear, its overall …

Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with
increased or reduced mTOR and GSK3β activity influences the wound repair process …

The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase
(PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of medicine today, the …

Human papillomavirus (HPV)-induced cancers will remain a significant clinical challenge for
decades. Thus, the development of novel treatment strategies is urgently required, which …