Fragment-Based Drug Design (FBDD) has established itself as a promising approach in
modern drug discovery, accelerating and improving lead optimization, while playing a …

Blood glucose (BG) concentration monitoring is essential for controlling complications
arising from diabetes, as well as digital management of the disease. At present, finger-prick …

Leishmaniasis and trypanosomiasis occur primarily in undeveloped countries and account
for millions of deaths and disability-adjusted life years. Limited therapeutic options, high …

Background: Leishmaniasis is a neglected disease that affects 15 million people around the
world. Many limitations are associated to the treatment as high cost and toxicity. Several …

We aimed to further explore the relationship between heterocyclic molecules and their
associated biological activities for acetylcholinesterase (AChE) and butyrylcholinesterase …

The transport of the molecules inside cells is a very important topic, especially in Drug
Metabolism. The experimental testing of the new proteins for the transporter molecular …

Computational techniques have proven to be an essential tool in modern drug discovery
research. These tools offer powerful methods for prediction of ligand–receptor interaction …

The study of the metabolism of xenobiotics by the human body is an essential stage in the
complex and expensive process of drug discovery, being one of the main causes of …

The discovery of anti-cancer agents is an area which continues in accelerated expansion.
Leukemias (Lkms) are among the most investigated cancers due to its high and dominant …

Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or
pharmacophores covalently linked in a single molecule. In the field of anti-infective agents …