[HTML][HTML] Blood GFAP as an emerging biomarker in brain and spinal cord disorders

A Abdelhak, M Foschi, S Abu-Rumeileh… - Nature Reviews …, 2022 - nature.com
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of …

M Amoo, J Henry, PJ O'Halloran, P Brennan… - Neurosurgical …, 2022 - Springer
Biomarkers such as calcium channel binding protein S100 subunit beta (S100B), glial
fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1) and neuron …

[HTML][HTML] GFAP and S100B: what you always wanted to know and never dared to ask

D Janigro, S Mondello, JP Posti, J Unden - Frontiers in neurology, 2022 - frontiersin.org
Traumatic brain injury (TBI) is a major global health issue, with outcomes spanning from
intracranial bleeding, debilitating sequelae, and invalidity with consequences for individuals …

Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration …

KKW Wang, FH Kobeissy, Z Shakkour… - Acute Medicine & …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) is a major cause of mortality and morbidity affecting all ages. It
remains to be a diagnostic and therapeutic challenge, in which, to date, there is no Food and …

Blood-based biomarkers for prediction of intracranial hemorrhage and outcome in patients with moderate or severe traumatic brain injury

TN Anderson, J Hwang, M Munar, L Papa… - Journal of trauma and …, 2020 - journals.lww.com
BACKGROUND Early identification of traumatic intracranial hemorrhage (ICH) has
implications for triage and intervention. Blood-based biomarkers were recently approved by …

The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury

F Kobeissy, RD Arja, JC Munoz, DA Shear… - Expert Review of …, 2024 - Taylor & Francis
Introduction Major organ-based in vitro diagnostic (IVD) tests like ALT/AST for the liver and
cardiac troponins for the heart are established, but an approved IVD blood test for the brain …

[HTML][HTML] One-year prospective study of plasma biomarkers from CNS in patients with mild traumatic brain injury

GJB Clarke, T Skandsen, H Zetterberg… - Frontiers in …, 2021 - frontiersin.org
Objective: To investigate the longitudinal evolution of three blood biomarkers: neurofilament
light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized …

Astrocytes in functional recovery following central nervous system injuries

QM Alhadidi, GA Bahader, O Arvola… - The Journal of …, 2023 - Wiley Online Library
Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

Label-free, ultrasensitive and rapid detection of FDA-approved TBI specific UCHL1 biomarker in plasma using MWCNT-PPY nanocomposite as bio-electrical …

P Supraja, S Tripathy, SRK Vanjari, SG Singh - Biosensors and …, 2022 - Elsevier
Abstract Traumatic Brain Injury (TBI), a major cause of mortality and neurological disability
affecting people of all ages worldwide, remains a diagnostic and therapeutic challenge to …

[HTML][HTML] Omega-3 fatty acids and vitamin D decrease plasma T-tau, GFAP, and UCH-L1 in experimental traumatic brain injury

AG Scrimgeour, ML Condlin, A Loban… - Frontiers in Nutrition, 2021 - frontiersin.org
Traumatic brain injury (TBI) results in neuronal, axonal and glial damage. Interventions
targeting neuroinflammation to enhance recovery from TBI are needed. Exercise is known to …