Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular
matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA …

The growing availability of single-cell and spatially resolved transcriptomics has led to the
development of many approaches to infer cell–cell communication, each capturing only a …

Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …

Introduction Subcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic
homeostasis. Persons with HIV (PWH) have an increased risk of metabolic diseases and …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

During fibrosis,(myo) fibroblasts deposit large amounts of extracellular matrix proteins,
thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of …

Cancer incidence and mortality are growing worldwide. With a lack of optimal treatments
across many cancer types, there is an unmet need for the development of novel treatment …

Fibrosis is a pathological condition characterized by the excessive deposition of
extracellular matrix components in tissues and organs, leading to progressive architectural …