Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Adult Development and Aging, 6th ed. Page 1 Page 2 John C. Cavanaugh Pennsylvania State
System of Higher Education Adult Development and Aging Fredda Blanchard-Fields Georgia …

Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …

Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Although recent advances in therapeutic approaches for treating HCC have …

Cancer-specific TERT promoter mutations (-146C> T and-124C> T) have been linked to
reactivation of the epigenetically silenced telomerase reverse transcriptase gene (TERT) …

Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …