Regulatory T cells, a subpopulation of suppressive T cells, are potent mediators of self-
tolerance and essential for the suppression of triggered immune responses. The immune …

Regulatory T (Treg) cells represent an essential component of peripheral tolerance. Given
their potently immunosuppressive functions that is orchestrated by the lineage-defining …

Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …

Tregs are key modulators of inflammation and are important for the maintenance of
peripheral tolerance. Adoptive immunotherapy with polyclonal Tregs holds promise in organ …

Periodontitis is a chronic immuno‐inflammatory disease in which the disruption of the
balance between host and microbiota interactions is key to the onset and progression of the …

Regulatory T cells (Tregs) have the role of regulating self-tolerance, and suppressing
immune responses. Defects in Treg function and number can lead to in loss of tolerance or …

Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and
immune tolerance; however, our understanding of CD8+ Tregs is limited while they are …

CD4+ regulatory T cells (Tregs) are a highly immune-suppressive subset of CD4+ T cells,
characterized by expression of the master regulatory transcription factor FOXP3. Tregs are …

Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise
worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal …

Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently
being clinically tested for their potential to stop or control undesired immune responses in …