Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Single-cell sequencing technologies have noteworthily improved our understanding of the
genetic map and molecular characteristics of bladder cancer (BC). Here we identify CD39 as …

Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …

During initiation of antiviral and antitumor T cell–mediated immune responses, dendritic
cells (DCs) cross-present exogenous antigens on major histocompatibility complex (MHC) …

Dendritic cells (DCs) are a complex network of specialised antigen-presenting cells that are
critical initiators of adaptive immunity. Targeting antigen directly to DCs in situ is a …