Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

The solubility advantage of amorphous solid dispersions (ASDs) is contingent upon
supersaturation being generated and maintained. If crystals are present within an ASD …

The implementation of clinically relevant drug product specifications (CRDPS) depends on
establishing a link between in vitro performance and in vivo exposure. The scientific …

Food can alter drug absorption and impact safety and efficacy. Besides conducting clinical
studies, in vitro approaches such as biorelevant solubility and dissolution testing and in vivo …

Entrectinib is a potent and selective tyrosine kinase inhibitor (TKI) of TRKA/B/C, ROS1, and
ALK with both systemic and CNS activities, which has recently received FDA approval for …

Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor
aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) …

This collection of contributions from the European Network on Understanding
Gastrointestinal Absorption-related Processes (UNGAP) community assembly aims to …

Due to the strong tendency towards poorly soluble drugs in modern development pipelines,
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …

Though oral drug delivery is the most preferred route of administration, there is high drug
pharmacokinetic variability associated with the oral route. Change in drug substance particle …