Many human diseases, including metabolic, immune and central nervous system disorders,
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …

Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …

Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …

The consumption of an olive oil rich diet has been associated with the diminished incidence
of cardiovascular disease and cancer. Several studies have attributed these beneficial …

Dysregulated lipid metabolism contributes to cancer progression. Our previous study
indicates that long-chain fatty acyl-Co A synthetase (ACSL) 3 is essential for lipid …

Fatty acid metabolism is essential for the biogenesis of cellular components and ATP
production to sustain proliferation of cancer cells. Long-chain fatty acyl-CoA synthetases …