Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine
pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A …

Results: The observed genotype frequencies for controls and BC patients were 1% and 2%
for Ins/Ins, 13% and 26% for W/Ins, and 86% and 72% for W/W, respectively. We found that …

This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential
biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross …

Despite the importance of one carbon metabolic pathway (OCMP) in modulating the DNA
methylation process, only a few population-based studies have explored their relationship …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage
and significant functional impairment. Methotrexate (MTX) remains the mainstay for the …

Background: The association of primary brain tumors with Single Nucleotide polymorphisms
(SNPs) in genes of folate metabolising enzymes have been reported to vary among different …

Down syndrome (DS) is the most common cause of mental retardation. Recent reports have
investigated possible genetic factors that may increase maternal risk for DS. Methionine …

Aim This study aimed to evaluate the role of methylenetetrahydrofolate dehydrogenase
(MTHFD 1) G1958A variant (rs2236225) as a 'maternal, paternal, or embryonic'genetic risk …

Objectives: Nonsyndromic cleft lip and palate (NSCLP) is genetically distinct from those with
syndromic clefts, and accounts for~ 70% of cases with Oral clefts. Folate, or vitamin B9, is an …