Purpose We conducted a retrospective evaluation of the IMCL-9815 study to examine the
association of human papillomavirus (HPV) and p16 protein expression status with …

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves
damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells …

Owing to the existence of severe tumor hypoxia and limited X-ray absorption of solid tumors,
the therapeutic efficacy of radiotherapy is far from satisfactory. Herein, ultrasmall iridium …

Purpose Promising results in a randomized phase II trial with the hypoxic cytotoxin
tirapazamine (TPZ) combined with cisplatin (CIS) and radiation led to this phase III trial …

Background Oral cavity and oropharyngeal cancers are frequently described as part of a
group of oral cancers or head and neck cancer. Treatment of oral cavity cancer is generally …

Background Three‐weekly high‐dose cisplatin (100 mg/m2) is considered the standard
systemic regimen given concurrently with postoperative or definitive radiotherapy in locally …

Oral cancer, as one of the most prevalent and invasive cancers that invade local tissue, can
cause metastasis, and have high mortality. In 2018, around 355,000 worldwide oral cancers …

PURPOSE Pembrolizumab is a humanized monoclonal antibody that blocks interaction
between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although …

Throughout the world, oral cancer is a common and aggressive malignancy with a high risk
of morbidity, mortality, and recurrence. The importance of early detection in cancer …

Purpose To determine the association between tumor hypoxia, treatment regimen, and
locoregional failure (LRF) in patients with stage III or IV squamous cell carcinoma of the …