Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment

K Sun, C Li, S Liao, X Yao, Y Ouyang, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of
regulated cell death resulting from abnormal iron metabolism involving the production of …

Ferroptosis: a new hunter of hepatocellular carcinoma

Y Jiang, Y Yu, Z Pan, C Glandorff, M Sun - Cell Death Discovery, 2024 - nature.com
Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular
lipid peroxidation that plays a key role in the development of HCC. Studies have shown that …

N6-methyladenosine (m6A) reader IGF2BP1 accelerates gastric cancer aerobic glycolysis in c-Myc-dependent manner

F Luo, K Lin - Experimental cell research, 2022 - Elsevier
Abstract The N 6-methyladenosine (m 6 A) is involved in the regulation of cell proliferation
and metastasis formation in multiple cancers. However, the biological significance of RNA m …

ALKBH5-mediated CHAC1 depletion promotes malignant progression and decreases cisplatin-induced oxidative stress in gastric cancer

C Chen, E Zhai, Y Liu, Y Qian, R Zhao, Y Ma… - Cancer Cell …, 2023 - Springer
The m6a demethyltransferase ALKBH5 dynamically modulates gene expression and
intracellular metabolic molecules by modifying RNA m6a in cancer cells. However …

[HTML][HTML] TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation

Y Sun, P Lin, X Zhou, Y Ren, Y He, J Liang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The transcription factor PBX1 is regarded as an oncogene in various cancers, but its role in
non-small cell lung cancer (NSCLC) and the detailed mechanism is not known. In the …

Endogenous chemicals guard health through inhibiting ferroptotic cell death

YH Song, HX Lei, D Yu, H Zhu, MZ Hao, RH Cui… - …, 2024 - Wiley Online Library
Ferroptosis is a new form of regulated cell death caused by iron‐dependent accumulation of
lethal polyunsaturated phospholipids peroxidation. It has received considerable attention …

Construction of a survival nomogram for gastric cancer based on the cancer genome atlas of m6A-related genes

X Wang, K Xu, X Liao, J Rao, K Huang, J Gao… - Frontiers in …, 2022 - frontiersin.org
Objective: Based on TCGA database, a prediction model for 1-, 3-, and 5-year overall
survival rates of gastric cancer (GC) patients was constructed by analyzing the critical risk …

Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer

W Dai, Y Liu, T Zhang, Z Huang, X Xu, Z Zhao, J Liu… - Oncogenesis, 2023 - nature.com
PBX1 is a transcription factor that regulates a variety of genes, involved in intracellular lipid
metabolism, cell proliferation, and other pathways. The promoting and inhibiting function of …

[HTML][HTML] RNA epigenetic modifications in digestive tract cancers: Friends or foes

Z Nian, M Deng, L Ye, X Tong, Y Xu, Y Xu… - Pharmacological …, 2024 - Elsevier
Digestive tract cancers are among the most common malignancies worldwide and have high
incidence and mortality rates. Thus, the discovery of more effective diagnostic and …

[HTML][HTML] PBX1 as a novel master regulator in cancer: Its regulation, molecular biology, and therapeutic applications

TW Kao, HH Chen, J Lin, TL Wang, YA Shen - Biochimica et Biophysica …, 2024 - Elsevier
PBX1 is a critical transcription factor at the top of various cell fate-determining pathways. In
cancer, PBX1 stands at the crossroads of multiple oncogenic signaling pathways and …