Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The skin is the human body's largest organ, colonized by a diverse milieu of
microorganisms, most of which are harmless or even beneficial to their host. Colonization is …

Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb
amputations and a shortened lifespan. However, molecular mechanisms contributing to the …

Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …

Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in
the filaggrin gene are the most significant known genetic risk factor for the development of …

Staphylococcus aureus colonization contributes to skin inflammation in diseases such as
atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S …

Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and
inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD …

Atopic dermatitis (AD) can be categorized into the extrinsic and intrinsic types. Extrinsic or
allergic AD shows high total serum IgE levels and the presence of specific IgE for …

The skin barrier would not function without IL-1 family members, but their physiological role
in the immunological aspects of skin barrier function are often overlooked. This review …

Loss-of-function mutations in the FLG (filaggrin) gene cause the semidominant keratinizing
disorder ichthyosis vulgaris and convey major genetic risk for atopic dermatitis (eczema) …