Epigenetic alterations caused by viral oncoproteins are strong initiation factors for cancer
development, but their mechanisms are largely unknown. To identify the epigenetic effects of …

AIM: To investigate the role of hepatitis B virus X-protein (HBx)-induced reactive oxygen
species (ROS) on liver carcinogenesis in HBx transgenic mice and HepG2-HBx cells …

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and has
the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has …

The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the
development of hepatocellular carcinoma (HCC). However, its possible contribution to the …

Hepatitis B virus (HBV) is a small hepatotropic and highly species-specific enveloped DNA
virus. The carcinogenicity of this virus has become focused on the X gene and its coded X …

Abstract Hepatitis B virus X (HBX) protein has been reported to induce upregulation of β-
catenin, a known proto-oncogene, in p53-knockout and p53-mutant hepatic cell lines both in …

Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis of chronically
infected HBV patients. To understand mechanism (s) of pX-mediated cellular transformation …

Background/Aims: The hepatitis B virus HBx protein is associated with the development of
hepatocellular carcinoma (HCC). However, its possible contribution to tumor spreading has …

The aim of this study was to investigate whether there was a particular hepatitis B virus
(HBV) X protein (HBx) mutant associated with Taiwanese patients with hepatocellular …

Background Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and
frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of …