HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators
SM Lee, Y Lee, JB Bae, JK Choi… - Proceedings of the …, 2014 - National Acad Sciences
Epigenetic alterations caused by viral oncoproteins are strong initiation factors for cancer
development, but their mechanisms are largely unknown. To identify the epigenetic effects of …
development, but their mechanisms are largely unknown. To identify the epigenetic effects of …
[HTML][HTML] HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway
HL Ha, DY Yu - World journal of gastroenterology: WJG, 2010 - ncbi.nlm.nih.gov
AIM: To investigate the role of hepatitis B virus X-protein (HBx)-induced reactive oxygen
species (ROS) on liver carcinogenesis in HBx transgenic mice and HepG2-HBx cells …
species (ROS) on liver carcinogenesis in HBx transgenic mice and HepG2-HBx cells …
Hepatitis B virus-induced hepatocellular carcinoma: the role of the virus x protein
Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and has
the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has …
the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has …
The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis
E Lara-Pezzi, JM Serrador, MC Montoya, D Zamora… - Hepatology, 2001 - Elsevier
The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the
development of hepatocellular carcinoma (HCC). However, its possible contribution to the …
development of hepatocellular carcinoma (HCC). However, its possible contribution to the …
Hepatitis B virus X gene is implicated in liver carcinogenesis
K Koike - Cancer letters, 2009 - Elsevier
Hepatitis B virus (HBV) is a small hepatotropic and highly species-specific enveloped DNA
virus. The carcinogenicity of this virus has become focused on the X gene and its coded X …
virus. The carcinogenicity of this virus has become focused on the X gene and its coded X …
Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
R Srisuttee, SS Koh, SJ Kim, W Malilas… - Oncology …, 2012 - spandidos-publications.com
Abstract Hepatitis B virus X (HBX) protein has been reported to induce upregulation of β-
catenin, a known proto-oncogene, in p53-knockout and p53-mutant hepatic cell lines both in …
catenin, a known proto-oncogene, in p53-knockout and p53-mutant hepatic cell lines both in …
[HTML][HTML] Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines
S Lee, C Tarn, WH Wang, S Chen, RL Hullinger… - Journal of Biological …, 2002 - ASBMB
Hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis of chronically
infected HBV patients. To understand mechanism (s) of pX-mediated cellular transformation …
infected HBV patients. To understand mechanism (s) of pX-mediated cellular transformation …
Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix
Background/Aims: The hepatitis B virus HBx protein is associated with the development of
hepatocellular carcinoma (HCC). However, its possible contribution to tumor spreading has …
hepatocellular carcinoma (HCC). However, its possible contribution to tumor spreading has …
Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma
CT Yeh, CH Shen, DI Tai, CM Chu, YF Liaw - Oncogene, 2000 - nature.com
The aim of this study was to investigate whether there was a particular hepatitis B virus
(HBV) X protein (HBx) mutant associated with Taiwanese patients with hepatocellular …
(HBV) X protein (HBx) mutant associated with Taiwanese patients with hepatocellular …
[HTML][HTML] Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3
KJ Kim, KH Kim, JH Cheong - PLoS One, 2010 - journals.plos.org
Background Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and
frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of …
frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of …