Dissecting the Role of Autophagy-Related Proteins in Cancer Metabolism and Plasticity
L Torres-López, O Dobrovinskaya - Cells, 2023 - mdpi.com
Modulation of autophagy as an anticancer strategy has been widely studied and evaluated
in several cell models. However, little attention has been paid to the metabolic changes that …
in several cell models. However, little attention has been paid to the metabolic changes that …
In vitro simulation of the acute lymphoblastic leukemia niche: a critical view on the optimal approximation for drug testing
I Pottosin, M Olivas-Aguirre… - Journal of Leukocyte …, 2023 - academic.oup.com
Acute lymphoblastic leukemia with the worst prognosis is related to minimal residual
disease. Minimal residual disease not only depends on the individual peculiarities of …
disease. Minimal residual disease not only depends on the individual peculiarities of …
Unveiling autophagy complexity in leukemia: The molecular landscape and possible interactions with apoptosis and ferroptosis
YY Jung, KS Ahn, M Shen - Cancer Letters, 2024 - Elsevier
Autophagy is a self-digestion multistep process in which causes the homeostasis through
degradation of macromolecules and damaged organelles. The autophagy-mediated tumor …
degradation of macromolecules and damaged organelles. The autophagy-mediated tumor …
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
HC Bwanika, IR Leo, N Struyf, A Talanti, L Aswad… - Scientific Reports, 2024 - nature.com
Autophagy is activated in response to a variety of stress conditions including anti-cancer
therapies, and tumors cells often depend on autophagy for survival. In this study, we have …
therapies, and tumors cells often depend on autophagy for survival. In this study, we have …
Leukemia and mitophagy: a novel perspective for understanding oncogenesis and resistance
Y Liu, Z Ma - Annals of Hematology, 2024 - Springer
Mitophagy, the selective autophagic process that specifically degrades mitochondria, serves
as a vital regulatory mechanism for eliminating damaged mitochondria and maintaining …
as a vital regulatory mechanism for eliminating damaged mitochondria and maintaining …
[HTML][HTML] Role of natural products in tumor therapy from basic research and clinical perspectives
Z Wang, Z Liu, J Qu, Y Sun, W Zhou - Acta Materia Medica, 2024 - scienceopen.com
Cancer is the leading cause of morbidity and mortality worldwide and is an important barrier
to lengthening life expectancy in every country. Natural products are receiving increased …
to lengthening life expectancy in every country. Natural products are receiving increased …
[HTML][HTML] Single-cell RNA sequencing reveals the effects of hederasaponin C in the treatment of diabetic nephropathy
J Liu, Q Zhang, W Zhao, J Guo, YK Wong… - Acta Materia …, 2023 - ucl.scienceopen.com
There is great demand for the development of novel efficient therapeutic strategies or
preventative measures to alleviate the life-threatening complications of type 2 diabetes …
preventative measures to alleviate the life-threatening complications of type 2 diabetes …
Beyond Corticoresistance, A Paradoxical Corticosensitivity Induced by Corticosteroid Therapy in Pediatric Acute Lymphoblastic Leukemias
L Angot, P Schneider, JP Vannier, S Abdoul-Azize - Cancers, 2023 - mdpi.com
Simple Summary Although remarkable progress in the treatment of acute lymphoblastic
leukemia (ALL) has been observed, some patients (~ 20%) relapse. Resistance to therapies …
leukemia (ALL) has been observed, some patients (~ 20%) relapse. Resistance to therapies …
Dexamethasone promotes autophagy dependent ferroptosis of placental trophoblast cells through GRα
HK Shang, Y Xu, J Lu, Q Xu, Z Ren - Authorea Preprints, 2023 - techrxiv.org
Objective: To investigate the mechanism by which DEX regulates ferroptosis through GRa
and autophagy to affect the function of placental trophoblast cells. Design: Exploration at …
and autophagy to affect the function of placental trophoblast cells. Design: Exploration at …
Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
Fasting is associated with improved outcomes in cancer. Here, we investigated the impact of
fasting on natural killer (NK) cell anti-tumor immunity. Cyclic fasting improved immunity …
fasting on natural killer (NK) cell anti-tumor immunity. Cyclic fasting improved immunity …