Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …

Sphingolipid signaling pathways have been implicated in many critical cellular events.
Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in …

The vascular endothelium is a critical regulator of vascular function. Diverse stimuli such as
proinflammatory cytokines and hemodynamic forces modulate endothelial phenotype and …

The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in
embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGF-C stimulates the …

The endothelium expresses a large repertoire of genes under apparent transcriptional
control of biomechanical forces, many of which are neither cell-type nor flow specific. We set …

In the face of systemic risk factors, certain regions of the arterial vasculature remain relatively
resistant to the development of atherosclerotic lesions. The biomechanically distinct …

Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain
pluripotency. These properties require transcription factors that specify the gene expression …

Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically
dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow …

Mammalian Kruppel-like transcription factors are implicated in regulating terminal
differentiation of several tissue types,,. Deficiency in Kruppel-like factor (KLF) 2 (also known …