Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart
disease. Such remodeling involves the production and destruction of extracellular matrix …

Krüppel-like factors are members of the zinc finger family of transcription factors that have
been implicated as playing key roles in regulating cellular differentiation and tissue …

Krüppel-like factors (KLFs) 1 are DNA-binding transcriptional regulators that play diverse
roles during differentiation and development. They form a subset of the broad class of …

The Krüppel-like factor (Klfs) family of gene regulatory proteins are transcription factors
implicated in many biological processes, including proliferation, apoptosis, differentiation …

The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory
cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro …

Recent advances in molecular cloning have led to the identification of a large number of
mammalian zinc finger-containing transcription factors that exhibit homology to the …

Lung Krüppel-like factor (LKLF/KLF2) is an endothelial transcription factor that is crucially
involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now …

The vascular endothelium maintains blood fluidity by inhibiting blood coagulation, inhibiting
platelet aggregation, and promoting fibrinolysis. Endothelial cells lose these …

The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

The advent of the genome projects has provided new avenues to explore the question of
how DNA sequence information is used appropriately by mammalian cells. Regulation of …