Objective: The transcription factor KLF2 is considered an important mediator of the anti-
inflammatory and anti-thrombotic properties of the endothelium. KLF2 is absent from low …

The pulmonary epithelial and vascular endothelial cell layers provide two sequential
physical and immunological barriers that together form a semi‐permeable interface and …

Objective The transcription factor Kruppel-like factor 2 (KLF2) modulates the expression of
multiple endothelial vasoprotective genes. In the absence of KLF2, the endothelial …

Flow patterns in blood vessels contribute to focal distribution of atherosclerosis; the
underlying mechanotransduction pathways remain to be investigated. We demonstrate that …

Recruitment of modifiers and remodelers to specific DNA sites within chromatin plays a
critical role in controlling gene expression. The study of globin gene regulation provides a …

Background and Purpose—The rupture of intracranial aneurysm (IA) causes subarachnoid
hemorrhage associated with high morbidity and mortality. We compared gene expression …

Self-renewal of embryonic stem cells (ESCs) is maintained by a complex regulatory
mechanism involving transcription factors Oct3/4 (Pou5f1), Nanog and Sox2. Here, we report …

Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted
on mice and humans have highlighted its importance in erythroid lineage commitment …

Krüppel-like factor 6 (KLF6) is a member of a growing family of transcription factors that
share a common 3 C2H2 zinc finger DNA binding domain and have broad activity in …

Vertebrates are endowed with a closed circulatory system, the evolution of which required
novel structural and regulatory changes. Furthermore, immune cell trafficking paradigms …