Tricuspid atresia (TA) is a common form of congenital heart disease, accounting for 1–3% of
congenital cardiac disorders 1. TA is characterized by the congenital agenesis of the …

Purpose: Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays important roles in
stem cells and the development of gastric cancers. However, the role of KLF4 in primary …

Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator
of activation, differentiation, and migration processes in various cell types. In this review, we …

The shear stress–induced transcription factor Krüppel-like factor 2 (KLF2) confers
antiinflammatory properties to endothelial cells through the inhibition of activator protein 1 …

Blood flow patterns play an important role in cardiovascular development, as changes can
cause congenital heart malformations. Shear stress is positively correlated to blood flow …

The Krüppel-like transcription factors (KLFs) are important regulators of cell proliferation and
differentiation in several different organ systems. The mouse Klf7 gene is strongly active in …

Impaired blood flow in the tumor vascular bed caused by structurally and functionally
abnormal blood vessels not only hinders the delivery of chemotherapeutic agents but also …

Krüppel-like factor 2 (KLF2) is a member of the KLF family of zinc-finger transcription factors
and is involved in maintaining T-cell quiescence, regulating preadipocyte differentiation …

Endothelial cells (ECs) lining blood vessels are exposed to mechanical forces, such as
shear stress. These forces control many aspects of EC biology, including vascular tone, cell …

Reciprocal interactions between vascular endothelial cells and vascular mesenchymal cells
are essential for angiogenesis. Here we show that the basic helix-loop-helix transcription …