Organ transplantation remains the only treatment option for patients with end-stage organ
failure. The last decade has seen a flurry of activity in improving organ preservation …

Dietary restriction promotes resistance to surgical stress in multiple organisms.
Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks …

Machine perfusion has developed rapidly since its first use in solid organ transplantation.
Likewise, reconstructive surgery has kept pace, and ex vivo perfusion appears as a new …

Background. Ex vivo kidney perfusion is an evolving platform that demonstrates promise in
preserving and rehabilitating the kidney grafts. Despite this, there is little consensus on the …

Background. In rodents, hydrogen sulfide (H 2 S) reduces ischemia-reperfusion injury and
improves renal graft function after transplantation. Here, we hypothesized that the benefits of …

Background. Brief normothermic machine perfusion is increasingly used to assess and
recondition grafts before transplant. During normothermic machine perfusion, metabolic …

The inability to preserve organs beyond several hours contributes to the scarcity of organs
for transplantation. To exacerbate the difficulty in organ preservation and to convene with the …

Static cold storage of donor livers at 4 C incompletely arrests metabolism, ultimately leading
to decreases in ATP levels, oxidative stress, cell death, and organ failure. Hydrogen Sulfide …