Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

Ischemia/reperfusion, which is characterized by deficient oxygen supply and subsequent
restoration of blood flow, can cause irreversible damages to tissue. Mechanisms contributing …

Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI),
remains a major cause of mortality worldwide. Despite the development of effective pre …

The authors hypothesized that despite similar cardiovascular event rates, the improved
cardiovascular survival from sodium glucose transporter 2 (SGLT2) inhibition, seen …

The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can
induce the expression of several downstream genes that play pivotal roles in the regulation …

Diabetic patients are at increased risk of developing coronary artery disease and experience
worse clinical outcomes following acute myocardial infarction. Novel therapeutic strategies …

The cardioprotection afforded by remote ischaemic conditioning (RIC) is mediated via a
complex mechanism involving sensory afferent nerves, the vagus nerve, and release of a …

New Findings What is the topic of this review? Remote ischaemic preconditioning (RIPC)
and hypoxic preconditioning as novel therapeutic approaches for cardiac and …

The two primary molecular regulators of lifespan are sirtuin-1 (SIRT1) and mammalian target
of rapamycin complex 1 (mTORC1). Each plays a central role in two highly interconnected …