Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular …

High-grade osteosarcomas are the most common primary malignant tumors of bone. With
complete surgical resection and multi-agent chemotherapy up to 70% of patients with high …

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …

Background: There is a lack of scientific consensus about cancer comorbidity in people with
central nervous system (CNS) disorders. This study assesses the co-occurrence of cancers …

Purpose The aim of this study was to investigate cancer incidence in a large cohort of
persons with Down syndrome. Methods Down syndrome was identified from the Danish …

Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …

The clinical and cytogenetic findings associated with mosaicism for trisomy 21/Down
syndrome are the focus of this review. The primary topics discussed in this overview of the …

Down syndrome is the most common chromosomal abnormality among live-born infants.
Through full or partial trisomy of chromosome 21, Down syndrome is associated with …