Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

There is considerable ambiguity in the use of terminology when referring to orofacial clefts
(OFCs). Many clinicians incorrectly refer to OFCs as deformities, which are said to be the …

With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …

Many factors influence human facial morphology, including genetics, age, nutrition,
biomechanical forces, and endocrine factors. Moreover, facial features clearly differ between …

Van der Woude syndrome (VWS) is an autosomal dominant malformation syndrome
characterized by orofacial clefting (OFC) and lower lip pits. The clinical presentation of VWS …

Nonsyndromic orofacial clefting (OFC) describes a range of phenotypes that represent the
most common craniofacial birth defects in humans, with an overall birth prevalence of 1: 700 …

Background Cleft lip and palate is one of the most common human birth defects, but the
underlying etiology is poorly understood. The A/WySn mouse is a spontaneously occurring …

Background Cleft lip and/or palate is among the most prevalent congenital birth defects, and
negatively affects maternal psychological status and may consequently result in higher …

We have applied a GWAS to 40 consanguineous families segregating cases of non-
syndromic cleft lip with or without cleft palate (NS CL/P)(a total of 160 affected and …

Non-syndromic cleft lip with or without palate (NSCL/P) is a frequent malformation of the
facial region. Genetic variants (SNPs) within nineteen loci have been previously associated …